Anthralin derivatives-inhibition of 5-lipoxygenase-antipsoriatic efficacy
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منابع مشابه
Anthralin derivatives--inhibition of 5-lipoxygenase--antipsoriatic efficacy.
Inhibition of 5-lipoxygenase by anthralin (1) and 41 derivatives is determined: the acids 38 and 39, the lactones 40-42 and 9-anthrone (8) are the most potent inhibitors, the lactone 41 reaching the efficacy of nordihydroguaiaretic acid (NDGA). The results were correlated with the hydrophilic/lipophilic balance of the test compounds and their clinical efficacy as far as known. There is no corre...
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Three new 5-lipoxygenase inhibitors, designated as BU-4601 A, B and C, were found in the fermentation broth of Streptomyces sp. strain No. AA2807. Their structures were identified as isodecyl, isoundecyl and isolauryl esters of 5-hydroxyanthranilic acid, respectively. Based on their structures, five related esters were synthesized and evaluated for biological activity as inhibitors of 5-lipoxyg...
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ژورنال
عنوان ژورنال: Archiv der Pharmazie
سال: 1991
ISSN: 0365-6233
DOI: 10.1002/ardp.2503241104